Hydrochloric Acid → trans-3-Amino-4-methoxypyrrolidine dihydrochloride

HRID 358900노트

반응식

HRID 358900 반응식
[ClH:1].[NH2:2][CH:3]1[CH:7]([O:8][CH3:9])[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1>C(O)C>[ClH:1].[ClH:1].[NH2:2][C@H:3]1[C@H:7]([O:8][CH3:9])[CH2:6][NH:5][CH2:4]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 20067140tert-Butyl 3-amino-4-methoxypyrrolidine-1-carboxylate

생성물 1

HCID 67925434trans-3-Amino-4-methoxypyrrolidine dihydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

6.3 ml of 6N aqueous hydrochloric acid were added to a solution of 0.4 g (0.0019 mole) of 3-amino-1-t-butoxycarbonyl-4-methoxypyrrolidine [prepared as described in Step (3) above] dissolved in 20 ml of ethanol, and the mixture was heated under reflux for 1.5 hours, after which the solvent was removed by evaporation under reduced pressure. The residue was washed with a 1:9 by volume mixture of ethanol and ethyl acetate to give 0.34 g of trans-3-amino-4-methoxypyrrolidine dihydrochloride as a colorless powder, melting at 248°~258° C. (with decomposition).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1.5 hours
  3. customafter which the solvent was removed by evaporation under reduced pressure
  4. washThe residue was washed with a 1:9 by volume mixture of ethanol and ethyl acetate

출처 및 근거

ORD 기록
ord-995b5ec61da5453f84f27d08bd551762
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04997943

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