Dimethylformamide → 4-(6-fluoro-1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide

HRID 359036

반응식

HRID 359036 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[N:7][N:8]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[N+]([NH:26][C:27](N)=[O:28])([O-])=O.CN(C)C=O>O>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([N:17]3[CH2:18][CH2:19][N:20]([C:27]([NH2:26])=[O:28])[CH2:21][CH2:22]3)=[N:7][N:8]2[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 62372NitroureaHCID 151171036-fluoro-1-phenyl-3-(1-piperazinyl)-1H-indazole

생성물 1

HCID 151171044-(6-fluoro-1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide수율 73%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4.5 g of 6-fluoro-1-phenyl-3-(1-piperazinyl)-1H-indazole, 4.3 g of nitrourea, and 75 ml of dimethylformamide was heated on a steam bath for 15 minutes. The reaction mixture was then poured into water and the resulting precipitate was recrystallized twice from toluene (one charcoal treatment) to yield 3.5 g (73%) of 4-(6-fluoro-1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide, m.p. 168°-170°.

후처리

  1. temperaturewas heated on a steam bath for 15 minutes
  2. customthe resulting precipitate was recrystallized twice from toluene (one charcoal treatment)

출처 및 근거

ORD 기록
ord-a52aa2785e414e96a9a2cf57086189c8
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04999356

연결된 노트

불러오는 중…