4-Chlorophenol → 1-Chloro-4-(4-nitrophenoxy)benzene

HRID 359070

반응식

HRID 359070 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[N+:9]([C:12]1[CH:17]=[CH:16][C:15](Br)=[CH:14][CH:13]=1)([O-:11])=[O:10].C(=O)([O-])[O-].[K+].[K+]>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:15]2[CH:16]=[CH:17][C:12]([N+:9]([O-:11])=[O:10])=[CH:13][CH:14]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 46844-ChlorophenolHCID 11430Potassium CarbonateHCID 114661-Bromo-4-nitrobenzene

생성물 1

HCID 157861-Chloro-4-(4-nitrophenoxy)benzene수율 95%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

p-Chlorophenol (7 g), p-nitrobromobenzene (11.0 g) and potassium carbonate (9.02 g) in dimethylsufoxide (35 ml) were heated with stirring at 120° C. for 24 hours and cooled, and the mixture was poured into water. The resulting precipitate was collected by filtration and washed with water. The resultant was heated in a mixed solvent of methanol/water [4:1,(v/v)], and allowed to cool. The resulting product was collected by filtration to give 4-(4-chlorophenoxy)nitrobenzene (12.92 g).

후처리

  1. temperaturecooled
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. temperatureThe resultant was heated in a mixed solvent of methanol/water [4:1,(v/v)], and
  5. temperatureto cool
  6. filtrationThe resulting product was collected by filtration

출처 및 근거

ORD 기록
ord-abd26f5b9827450e90a5f585c85651fe
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04999378

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