Ethyl Acetate → 2-(4-Chlorophenylamino)-1-cyclopentanemethanol

HRID 359103노트

반응식

HRID 359103 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][CH:15]2[CH2:19][CH2:18][CH2:17][CH:16]2[C:20](OCC)=[O:21])=[CH:10][CH:9]=1.C(OCC)(=O)C.[OH-].[Na+]>C1COCC1>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([NH:14][CH:15]2[CH2:19][CH2:18][CH2:17][CH:16]2[CH2:20][OH:21])=[CH:12][CH:13]=1

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 15086642HCID 15086642, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 150866432-(4-Chlorophenylamino)-1-cyclopentanemethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Lithium aluminum hydride (1.60 g) was suspended in THF (70 ml) under ice cooling and thereto a solution of ethyl 2-(4-chlorophenylamino)-1-cyclopentanecarboxylate in THF (about 16 ml) was added gradually, and the mixture was stirred at room temperature for 14 hours. Ethyl acetate and a small amount of 1N aqueous sodium hydroxide solution were added to the reaction mixture to decompose the excess reducing agent. The mixture was filtered and concentrated under reduced pressure to give the oily desired product (3.24 g).

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-832612e110bc4d3bbdc70a649c98c860
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04999378

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