Thioglycolic Acid → 2-(Tritylthio)acetic acid

HRID 359130노트

반응식

HRID 359130 반응식
[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[SH:21][CH2:22][C:23]([OH:25])=[O:24]>FC(F)(F)C(O)=O>[C:7]([S:21][CH2:22][C:23]([OH:25])=[O:24])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 1133Thioglycolic AcidHCID 6457Triphenylcarbinol

생성물 1

HCID 42453062-(Tritylthio)acetic acid수율 94.4%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

This compound was synthesized by the condensation of triphenylmethanol (2.84 g, 10.8 mmoles) with mercaptoacetic acid (0.75 ml, 10.8 mmoles) in 19 ml trifluoracetic acid. The TFA was removed in vacuo, giving an orange oil, which was purified by dissolution in ether and extraction with 1 N NaOH. The aqueous phase was acidified with 6N HCl, and extracted with two 30 ml portions of ether. The ethereal phase was dried over MgSO4 and evaporated to give 3.41 g (93%) of a white solid.

후처리

  1. customThe TFA was removed in vacuo
  2. customgiving an orange oil, which
  3. customwas purified by dissolution in ether
  4. extractionextraction with 1 N NaOH
  5. extractionextracted with two 30 ml portions of ether
  6. dry with materialThe ethereal phase was dried over MgSO4
  7. customevaporated

출처 및 근거

ORD 기록
ord-3491d70d6f84495783e0f1a510576c8c
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04999424

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