Hydrochloric Acid → 1-(6-Chloropyridazin-3-yl)piperidin-4-amine
반응식
[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14]C(=O)OCC)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1참가 물질
3
실험 절차
A mixture of 6 parts of ethyl [1-(6-chloro-3-pyridazinyl)-4-piperidinyl]carbamate and 60 parts of concentrate hydrochloric acid was stirred and refluxed for 24 hours. The reaction mixture was evaporated. Water was added and the whole was treated with concentrate ammonium hydroxide. The product was extracted with trichloromethane. The extract was dried, filtered and evaporated, yielding 3.8 parts (82%) of 1-(6-chloro-3-pyridazinyl)-4-piperidinamine: mp. 260° C. (dec.) (compound 225).
후처리
- temperaturerefluxed for 24 hours
- customThe reaction mixture was evaporated
- additionWater was added
- additionthe whole was treated with concentrate ammonium hydroxide
- extractionThe product was extracted with trichloromethane
- customThe extract was dried
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-6864f4d4dfb84a81840eb42284f6bedb
- 출처 데이터셋
- uspto-grants-1991_03
- 특허 번호
- US05001125
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