Sulfuric Acid → 7-Hydroxy-4,6-dimethyl-2H-1-benzopyran-2-one

HRID 359496

반응식

HRID 359496 반응식
[OH:1][C:2]1C=C(O)[CH:5]=[CH:4][C:3]=1[CH3:9].OS(O)(=O)=O.[CH2:15]([O:17][C:18](=[O:23])[CH2:19][C:20]([CH3:22])=O)[CH3:16]>>[CH3:22][C:20]1[C:5]2[C:15](=[CH:16][C:2]([OH:1])=[C:3]([CH3:9])[CH:4]=2)[O:17][C:18](=[O:23])[CH:19]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 8868Ethyl AcetoacetateHCID 103331,3-Benzenediol, 4-methyl-

생성물 1

HCID 107977397-Hydroxy-4,6-dimethyl-2H-1-benzopyran-2-one

실험 절차

A solution of 2,4-dihydroxytoluene (10.0 g) in ethylacetoacetate (12 ml) was poured in small portion into conc. H2SO4 (26 ml), chilling in an ice bath. After the addition was completed the solid obtained was separated by filtration, washed several times with water up to neutrality of the washings, dried and crystallized from MeOH, yielding 4,6-dimethyl-7-hydroxycoumarin (III) (10.64 g; m.p. 273° C.). ##STR9##

후처리

  1. temperaturechilling in an ice bath
  2. additionAfter the addition
  3. customobtained
  4. customwas separated by filtration
  5. washwashed several times with water up to neutrality of the washings
  6. customdried
  7. customcrystallized from MeOH

출처 및 근거

ORD 기록
ord-d9d006fbc7f34f76bf56b49995c94735
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05001147

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