Gamma-Butyrolactone → HCID 178520699, 화합물

반응식

[O:1]([C@H:5]1[CH2:10][CH2:9][C@H:8]([NH2:11])[CH2:7][CH2:6]1)[N+:2]([O-:4])=[O:3].[C:12]1(=[O:17])[O:16][CH2:15][CH2:14][CH2:13]1>>[OH:17][CH2:12][CH2:13][CH2:14][C:15]([NH:11][C@H:8]1[CH2:7][CH2:6][C@H:5]([O:1][N+:2]([O-:4])=[O:3])[CH2:10][CH2:9]1)=[O:16]

참가 물질

반응물 2

HCID 7302Gamma-Butyrolactone

HCID 178511725HCID 178511725, 화합물

생성물 1

HCID 178520699HCID 178520699, 화합물

실험 절차

4.8 g (0.03 mol) trans-4-nitroxycyclohexylamine are mixed with 5.7 ml 4-butyrolactone and stirred for 3 d at room temperature. For the removal of the excess lactone, it is filtered over a silicic gel acid with ethyl acetate. After collection of the pure fractions, it is distilled in a vacuum, triturated with ether and filtered off with suction. There remain 2.1 g of the title compound of the melting point 58°-60° C., i.e. 28% of theory.

후처리

customFor the removal of the excess lactone, it
filtrationis filtered over a silicic gel acid with ethyl acetate
customAfter collection of the pure fractions, it
distillationis distilled in a vacuum
customtriturated with ether
filtrationfiltered off with suction

출처 및 근거

ORD 기록: ord-804ea5da64ca4972b7c3a4735b112a1e
출처 데이터셋: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05411989

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