Ethanolamine → N-(2-hydroxyethyl)nicotinamide

HRID 359874

반응식

[C:1]([O:9]CC)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[CH2:12]([CH2:14][NH2:15])[OH:13]>>[OH:13][CH2:12][CH2:14][NH:15][C:1]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1)=[O:9]

참가 물질

반응물 2

HCID 700Ethanolamine

HCID 69188Ethyl Nicotinate

생성물 1

HCID 72663N-(2-hydroxyethyl)nicotinamide수율 85.1%

실험 절차

A solution of 49.2 g (0.32525 mol) ethyl nicotinate and 72 g (1.17 mol) ethanolamine was heated at 70° C. for 60 hours. The excess ethanolamine was removed under reduced pressure and the resulting viscous cream oil was stirred with ether for 48 hours. The resulting white solid was removed by filtration, affording 46 g (85.1%) of the title compound melting at 75°-78° C.

후처리

customThe excess ethanolamine was removed under reduced pressure
customThe resulting white solid was removed by filtration

출처 및 근거

ORD 기록: ord-d75f9f418ccc4c9a9128f3b7711a460b
출처 데이터셋: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05002935

연결된 노트

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