2-Methoxybenzonitrile → 5-(2-Methoxyphenyl)-1H-tetrazole
반응식
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH3:10])#[N:2].C([Sn]([N:24]=[N+:25]=[N-:26])(CCCC)CCCC)CCC>C1(C)C(C)=CC=CC=1.C(OCC)C>[CH3:10][O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:1]1[N:24]=[N:25][NH:26][N:2]=1참가 물질
5
실험 절차
A mixture of 1-cyano-2-methoxybenzene (1.02 g, 7.7 mmol) and tributyltin azide (3.4 g, 10.0 mmol) in 3.0 mL of xylene was heated under reflux for hours. The reaction mixture then was cooled and diluted with diethyl ether. Anhydrous hydrochloric acid was bubbled into the mixture and a white precipitate formed. The precipitate was collected by suction filtration and washed repeatedly with diethyl ether. Drying gave 5-(2-methoxyphenyl)-2H-tetrazole (1.33 g, 7.55 mmol).
후처리
- temperaturewas heated
- temperatureunder reflux for hours
- temperatureThe reaction mixture then was cooled
- customAnhydrous hydrochloric acid was bubbled into the mixture
- customa white precipitate formed
- filtrationThe precipitate was collected by suction filtration
- washwashed repeatedly with diethyl ether
- customDrying
출처 및 근거
- ORD 기록
- ord-bebdd46407ed4d14828dd44daa521bd6
- 출처 데이터셋
- uspto-grants-1995_05
- 특허 번호
- US05412102
반응 노트
불러오는 중…