1-Bromopentane → 3-Bromophenol

HRID 36148

반응식

HRID 36148 반응식
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH2:16]([O:8][CH2:4][CH2:5][CH2:6][CH2:7][CH3:2])[CH2:17][CH2:18][CH2:19][CH3:20]

참가 물질

6

반응물 3

HCID 80571-BromopentaneHCID 11430Potassium CarbonateHCID 115633-Bromophenol

생성물 2

HCID 115633-BromophenolHCID 12743Pentyl ether

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

To a solution of 5.0 gm of 3-Bromophenol in 60 mls of dimethylformamide is added 6.0 gm of potassium carbonate followed by 4.3 ml of 1-bromopentane. This mixture is heated to 60° C. for 6 hours and then cooled to room temperature and filtered. The filtrate is diluted with ether and washed with water and brine. After drying over magnesium sulfate and concentrating, the crude oil obtained is chromatographed over silica gel, and eluted with 3:2 hexane:ether to yield 3-bromo-phenol, n-pentyl ether as a clear oil.

후처리

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. additionThe filtrate is diluted with ether
  4. washwashed with water and brine
  5. dry with materialAfter drying over magnesium sulfate
  6. concentrationconcentrating
  7. customthe crude oil obtained
  8. customis chromatographed over silica gel
  9. washeluted with 3:2 hexane

출처 및 근거

ORD 기록
ord-de9358811e8a412f9a03ad3430e27453
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05412137

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