홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Sulfide → 3-Acetoxy-7alpha-(5-acetoxypentyl)-16alpha-bromo-17,17-ethylenedioxy-estra-1,3,5(10)-triene

HRID 361642
노트
인쇄 미리보기

반응식

HRID 361642 반응식
[C:1]([O:4][C:5]1[CH:22]=[CH:21][C:20]2[C@@H:19]3[C@H:10]([C@H:11]4[C@@:15]([CH2:17][CH2:18]3)([CH3:16])[C:14]3([O:26][CH2:25][CH2:24][O:23]3)[CH2:13][CH2:12]4)[C@H:9]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][O:32][C:33](=[O:35])[CH3:34])[CH2:8][C:7]=2[CH:6]=1)(=[O:3])[CH3:2].C1C=C[NH+]=CC=1.[Br:42][Br-]Br.[S-2].[Na+].[Na+]>O1CCCC1.O.C(OCC)(=O)C>[C:1]([O:4][C:5]1[CH:22]=[CH:21][C:20]2[C@@H:19]3[C@H:10]([C@H:11]4[C@@:15]([CH2:17][CH2:18]3)([CH3:16])[C:14]3([O:26][CH2:25][CH2:24][O:23]3)[C@H:13]([Br:42])[CH2:12]4)[C@H:9]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][O:32][C:33](=[O:35])[CH3:34])[CH2:8][C:7]=2[CH:6]=1)(=[O:3])[CH3:2]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 14804Sodium SulfideHCID 15838160HCID 15838160, 화합물

생성물 1

HCID 158381613-Acetoxy-7alpha-(5-acetoxypentyl)-16alpha-bromo-17,17-ethylenedioxy-estra-1,3,5(10)-triene수율 100.8%

시약·촉매·용매 3

HCID 962Water용매HCID 8028Tetrahydrofuran용매
HCID 8857
Ethyl Acetate
용매

반응 조건

온도
0 °C

실험 절차

A solution of 63.2 g of 3-acetoxy-7α-(5-acetoxypentyl)-17,17-ethylenedioxy-estra-1,3,5(10)-triene in 630 ml of tetrahydrofuran is mixed in portions at 0° C. with 61.7 g of pyridine hydrobromide perbromide, and it is stirred for 2 hours at 0° C. Then, a solution of 15 g of sodium sulfide in 70 ml of water is added, diluted with ethyl acetate, washed with sodium bicarbonate and common salt solution and dried on sodium sulfate and concentrated by evaporation in a vacuum. 74.1 g of 3-acetoxy-7α-(5-acetoxypentyl)-16α-bromo-17,17-ethylenedioxy-estra-1,3,5(10)-triene is obtained as oil.

후처리

  1. washwashed with sodium bicarbonate and common salt solution
  2. customdried on sodium sulfate
  3. concentrationconcentrated by evaporation in a vacuum

출처 및 근거

ORD 기록
ord-99ccf0ea848a43739ebcc4275b7c7031
출처 데이터셋
uspto-grants-1999_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05866560

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트