3-Cyclohexyl-L-alanine → Methyl 3-cyclohexyl-L-alaninate
반응식
N1CCC(CCCC(N(CC)CC(N[C@H](C([NH:24][C@H:25]([C:33]([OH:35])=[O:34])[CH2:26][CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)=O)CC(=O)O)=O)=O)CC1.[CH:38]1(C[C@@H](C(O)=O)N)CCCCC1>CO.Cl>[CH3:38][O:35][C:33](=[O:34])[C@H:25]([CH2:26][CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]1)[NH2:24]참가 물질
5
실험 절차
N-[N-[N-(4-(piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine ##STR6##A. β-cyclohexylalanine (1.12 g) is dissolved in of methanol (50 ml) and hydrogen chloride gas is bubbled through the solution for about 15 minutes. The solution is evaporated in vacuo and toluene azeotroped from the residue to give β-cyclohexyl-L-alanine methyl ester as the hydrochloride salt.
후처리
- customis bubbled through the solution for about 15 minutes
- customThe solution is evaporated in vacuo and toluene
- customazeotroped from the residue
출처 및 근거
- ORD 기록
- ord-e417ce7af4614a46b0fa417b1b4b4153
- 출처 데이터셋
- uspto-grants-1999_02
- 특허 번호
- US05866685
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