Lithium azide → [2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl azide

HRID 36187

반응식

HRID 36187 반응식
[C:1]([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:20]=[CH:19][C:18]([CH2:21]Br)=[CH:17][CH:16]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[N-:23]=[N+:24]=[N-:25].[Li+]>>[C:1]([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:23]=[N+:24]=[N-:25])=[CH:17][CH:16]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 88163Lithium azideHCID 15282100[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl bromide

생성물 1

HCID 10427616[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl azide수율 74%

실험 절차

Reaction of [2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl bromide (from Step D) with lithium azide was carried out according to the procedure of Example 9, Step A. The crude product was purified by flash chromatography on silica gel (elution with 10% EtOAc in hexane) to give a 74% yield of the title compound as a white solid; satisfactory purity (by TLC in 9:1 hexane-EtOAc) for use in the next step.

후처리

  1. customThe crude product was purified by flash chromatography on silica gel (elution with 10% EtOAc in hexane)

출처 및 근거

ORD 기록
ord-5b582a3dfc904b129bd9856a7382c53f
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05411980

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