Ammonia → HCID 57186127, 화합물

HRID 361895노트

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HRID 361895 반응식
C(O[C:6]([N:8]1[CH2:12][CH2:11][C@H:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([CH:20]([CH2:26][C:27]3[O:28][C:29]4[CH:35]=[CH:34][C:33]([C:36]#[N:37])=[CH:32][C:30]=4[CH:31]=3)[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:16][CH:15]=2)[CH2:9]1)=O)(C)(C)C.C=O.C(Cl)(Cl)Cl.N>C(O)=O>[C:36]([C:33]1[CH:34]=[CH:35][C:29]2[O:28][C:27]([CH2:26][CH:20]([C:17]3[CH:18]=[CH:19][C:14]([O:13][C@H:10]4[CH2:11][CH2:12][N:8]([CH3:6])[CH2:9]4)=[CH:15][CH:16]=3)[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:31][C:30]=2[CH:32]=1)#[N:37]

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 712FormaldehydeHCID 6212ChloroformHCID 10323852ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzofuranyl)propionate

생성물 1

HCID 57186127HCID 57186127, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매2회

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온도
70 °C

실험 절차

1.8 g of ethyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-benzofuranyl)-propionate was dissolved in 28 ml of formic acid, and the solution was stirred at 70° C. for 1 hour. The resulting reaction solution was concentrated to dryness, and the residue thus obtained was dissolved in 8 ml of formic acid. 0.29 ml of 37% formaldehyde was added thereto, and then refluxed under heating for 4 hours. After cooling, the reaction solution was mixed with chloroform, and then adjusted to pH 10-11 with aqueous ammonia, and the resulting organic layer was collected and dried.

후처리

  1. customThe resulting reaction solution
  2. concentrationwas concentrated to dryness
  3. customthe residue thus obtained
  4. temperaturerefluxed
  5. temperatureunder heating for 4 hours
  6. temperatureAfter cooling
  7. customthe resulting organic layer was collected
  8. customdried

출처 및 근거

ORD 기록
ord-728a7c5598e141a6a3ddc61251e5cfbd
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866577

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