Ammonia → 4-Hydroxymethyl-2,5-dimethylphenol

HRID 361973

반응식

HRID 361973 반응식
[C:1]1([OH:9])[C:2]([CH3:8])=[CH:3][CH:4]=[C:5]([CH3:7])[CH:6]=1.[OH-:10].[Na+].[CH2:12]=O.N>C(O)(=O)C.O>[OH:10][CH2:12][C:4]1[C:5]([CH3:7])=[CH:6][C:1]([OH:9])=[C:2]([CH3:8])[CH:3]=1

참가 물질

7

반응물 4

HCID 222AmmoniaHCID 712FormaldehydeHCID 72672,5-DimethylphenolHCID 14798Sodium Hydroxide

생성물 1

HCID 109426404-Hydroxymethyl-2,5-dimethylphenol

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

반응 조건

온도
12 °C

실험 절차

Into a 5 liter four-necked flask were charged 610.9 g of 2,5-xylenol, 200 gof sodium hydroxide and 2500 g of water. While stirring at 12° C., 565 g of 37% formaldehyde was added dropwise thereto over 1 hour and 30 minutes, and the reaction was conducted for 4 more hours. After completionof the reaction, 89 g of 28% aqueous ammonia solution was added and the mixture was stirred for 30 minutes. Thereafter, 400 g of acetic acid was added thereto, and the resulting mixture was filtered and washed with water. The filtered product thus obtained was dried to obtain 609 g of 4-hydroxymethyl-2,5-dimethylphenol. Purity measured by liquid chromatography (LC): 99%

후처리

  1. custom30 minutes
  2. additionwas added
  3. stirringthe mixture was stirred for 30 minutes
  4. filtrationthe resulting mixture was filtered
  5. washwashed with water
  6. customThe filtered product thus obtained
  7. customwas dried

출처 및 근거

ORD 기록
ord-78fd208b70014bb693819b515af4127a
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866724

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