Ethanol → 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide dihydrate

HRID 362253

반응식

HRID 362253 반응식
[Br:1][CH2:2][C:3]([C:5]1[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[S:8][CH:9]=1)=[O:4].[NH:14]1[CH2:18][CH2:17][NH:16][C:15]1=[S:19].C([OH:22])C>C(O)(=O)C>[OH2:4].[OH2:22].[BrH:1].[S:8]1[CH:9]=[C:5]([C:3]2[N:16]3[CH2:17][CH2:18][N:14]=[C:15]3[S:19][CH:2]=2)[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]1=2

참가 물질

5

반응물 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 27763411-(1-Benzothiophen-3-yl)-2-bromoethan-1-one

생성물 1

HCID 687790213-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide dihydrate

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 3-(2-bromoacetyl)benzo[b]thiophen (2.39 g), 2-imidazolidinethione (0.78 g), ethanol (60 ml) and acetic acid (40 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ether (2×50 ml), and dried in vacuo at ambient temperature to give 3-(benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1 -b]thiazole monohydrobromide dihydrate as a white solid (2.96 g), m.p. 239°-240° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with ether (2×50 ml)
  5. customdried in vacuo at ambient temperature

출처 및 근거

ORD 기록
ord-fd09965459ef41efa16387e585faa295
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869492

연결된 노트

불러오는 중…