Sodium Hydroxide → HCID 70284941, 화합물

HRID 362263노트

반응식

HRID 362263 반응식
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][C:7]([CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)([OH:10])[C:8](=[CH2:9])[C:4]=2[CH:3]=1.[OH-].[Na+]>ClCCl>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][CH2:9][CH:8]([C:7](=[O:10])[CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 70284478HCID 70284478, 화합물

생성물 1

HCID 70284941HCID 70284941, 화합물수율 97%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 5-chloro-3-methylene-2-phenoxymethyl-2,3-dihydrobenzo[b]-thiophen-2-ol (16.9 g) in dichloromethane (250 ml) was shaken vigorously for a few seconds with 5M aqueous sodium hydroxide solution (150 ml), then the organic solution was separated, washed with water (150 ml), dried (MgSO4), and the solvent removed in vacuo to leave 1-(5-chloro-2,3-dihydrobenzo[b]thiophen-3-yl)-2-phenoxyethanone as a pink solid (16.4 g) which was used without further purification.

후처리

  1. customthe organic solution was separated
  2. washwashed with water (150 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-9e35c27a97f1484c816c2e9d40480353
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869492

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