Methanol → 4-[(2-methoxyanilino)methylidene]-5-methyl-2-phenylpyrazol-3-one

HRID 362451

반응식

HRID 362451 반응식
[CH3:1][C:2]1[CH2:3][C:4](=[O:13])[N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[CH:14](OC)(OC)OC.[CH3:21][O:22][C:23]1[C:24]([NH2:29])=[CH:25][CH:26]=[CH:27][CH:28]=1.CO>C(O)(=O)C>[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[NH:29][CH:14]=[C:3]1[C:2]([CH3:1])=[N:6][N:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:4]1=[O:13]

참가 물질

6

반응물 4

HCID 887MethanolHCID 4021Mci-186HCID 70002-MethoxyanilineHCID 9005Trimethyl orthoformate

생성물 1

HCID 1784895884-[(2-methoxyanilino)methylidene]-5-methyl-2-phenylpyrazol-3-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2 g of 5-methyl-2-phenyl-2,4-dihydro-3-pyrazolone, 188 ml of trimethyl orthoformate and 1.29 ml of o-anisidine are heated with stirring in 5 ml of glacial acetic acid at 70° C. for 2 h. The reaction mixture is cooled and 10 ml of methanol are added. The precipitate which has separated out is filtered off with suction and recrystallized from ethyl acetate.

후처리

  1. temperatureThe reaction mixture is cooled
  2. customThe precipitate which has separated out
  3. filtrationis filtered off with suction
  4. customrecrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-a5a8ea6e2454456faa5d8fdb3e022197
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05869516

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