Hydrochloric Acid → Lesopitron dihydrochloride

HRID 362778노트

반응식

HRID 362778 반응식
[CH:1]1[CH:2]=[N:3][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]3[N:21]=[CH:20][C:19]([Cl:22])=[CH:18]3)[CH2:9][CH2:8]2)=[N:5][CH:6]=1.[ClH:23]>C(O)(C)C>[CH2:9]1[N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[N:21]=[CH:20][C:19]([Cl:22])=[CH:18]2)[CH2:11][CH2:12][N:7]([C:4]2[N:3]=[CH:2][CH:1]=[CH:6][N:5]=2)[CH2:8]1.[ClH:23].[ClH:22]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 60813Lesopitron

생성물 1

HCID 60812Lesopitron dihydrochloride수율 195.5%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A 250 L enamelled reactor was loaded with an isopropanolic solution (57 Kg) of Lesopitron (25.2 mol), and was cooled to 5°-10° C. Subsequently, 8.5 Kg of a solution of hydrochloric acid (58.3 mol) in isopropanol were added, keeping the temperature between 5° and 15° C. during the addition. After stirring the suspension for 30 minutes, the product was centrifuged and washed with isopropanol. The Lesopitron dihydrochloride was washed and then dried in an air oven at 40° C. for 15 hours, obtaining 9.7 Kg (98% yield) of the compound mentioned in the title.

후처리

  1. temperaturewas cooled to 5°-10° C
  2. customthe temperature between 5° and 15° C.
  3. additionduring the addition
  4. washwashed with isopropanol
  5. washThe Lesopitron dihydrochloride was washed
  6. customdried in an air oven at 40° C. for 15 hours

출처 및 근거

ORD 기록
ord-57d25957bbf443e6b00767cf1aa41038
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872125

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