Sodium Hydroxide → 3-(2-Fluorophenyl)propanoic acid

HRID 362829노트

반응식

HRID 362829 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([O:12]CC)=[O:11].[OH-].[Na+]>O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([OH:12])=[O:11]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 14879014Ethyl 3-(2-fluorophenyl)propanoate

생성물 1

HCID 20638663-(2-Fluorophenyl)propanoic acid수율 85.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of ethyl 3-(2-fluorophenyl)propionate (25.54 g, 0.130 mol) and a 50% aqueous solution of sodium hydroxide (30 mL) in water (130 mL) was refluxed for 2 h. After cooling the mixture was washed with diethyl ether (2×100 mL). The aqueous phase was chilled in an ice bath, and the pH was adjusted to 3 with hydrochloric acid . The white precipitate which formed was collected by filtration, washed repeatedly with water, and dried in a vacuum at 60° C. for 18 h to give 18.66 g (85%) of 3-(2-fluorophenyl)propionic acid as a white solid; m.p., 72°-74° C. This material was used without further purification.

후처리

  1. temperatureAfter cooling the mixture
  2. washwas washed with diethyl ether (2×100 mL)
  3. temperatureThe aqueous phase was chilled in an ice bath
  4. customThe white precipitate which formed
  5. filtrationwas collected by filtration
  6. washwashed repeatedly with water
  7. customdried in a vacuum at 60° C. for 18 h

출처 및 근거

ORD 기록
ord-e32e5ff2b6084dcab673d88d7df6f0ba
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872118

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