Hydrogen Bromide → 2-Fluorophenethyl bromide

반응식

[BrH:1].S(=O)(=O)(O)O.[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15]O>>[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][Br:1]

참가 물질

반응물 3

HCID 260Hydrogen Bromide

HCID 1118Sulfuric Acid

HCID 27332962-(2-Fluorophenyl)ethan-1-ol

생성물 1

HCID 27569642-Fluorophenethyl bromide수율 99%

실험 절차

To a mixture of aqueous hydrobromic acid (48%, 360 mL) and concentrated sulfuric acid (103.6 mL) at room temperature was added dropwise 2-(2-fluorophenyl)ethanol (250 g, 1.78 mol, Aldrich). The reaction mixture was refluxed for 7 h, poured onto 600 ml of ice and the mixture was extracted with diethyl ether. The diethyl ether extracts were washed successively with saturated sodium carbonate and brine. The organic phase was dried (MgSO4) and concentrated in vacuo to give 359.9 g (99%) of 2-(2-fluorophenyl)-ethylbromide as a brown oil. This product was used without further purification. NMR (CDCl3 : d 7.6-6.9 (m. 4H, ArH), 3.6 (t, 2H CH2), 3.2 (t, 2H, CH2).

후처리

temperatureThe reaction mixture was refluxed for 7 h
extractionthe mixture was extracted with diethyl ether
washThe diethyl ether extracts were washed successively with saturated sodium carbonate and brine
dry with materialThe organic phase was dried (MgSO4)
concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-94c84f6978a34477bbb058ea20e1f0a0
출처 데이터셋: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05872118

반응 노트

불러오는 중…