Water → 1-(2-Phthalimidoethyl)-4,5-diphenylimidazole

HRID 362895노트

반응식

HRID 362895 반응식
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].Cl[CH2:14][CH2:15][N:16]1[C:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[C:19]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:18]=[CH:17]1.O>CN(C=O)C.C(Cl)(Cl)Cl>[C:1]1(=[O:11])[N:5]([CH2:14][CH2:15][N:16]2[C:20]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[C:19]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[N:18]=[CH:17]2)[C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12

참가 물질

6

반응물 3

HCID 962WaterHCID 24194345Phthalimide potassium saltHCID 542225981-(2-Chloroethyl)-4,5-diphenylimidazole

생성물 1

HCID 539687861-(2-Phthalimidoethyl)-4,5-diphenylimidazole수율 73%

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 6228Dimethylformamide용매

실험 절차

Step 2): A mixture of potassium phthalimide (0.21 g, 1.1 mmol) and 1-(2-chloroethyl)-4,5-diphenylimidazole (0.32 g, 1.1 mmol) in dry DMF (10 ml) was heated at 60°-70° C. for 6 hours. The reaction mixture was cooled, diluted with chloroform, poured into water and extracted with chloroform. The organic layer was dried (MgSO4) and concentrated. The residue was purified by column chromatography on silica gel (40% ethyl acetate in chloroform) to give 1-(2-phthalimidoethyl)-4,5-diphenylimidazole (73.0%).

후처리

  1. temperaturewas heated at 60°-70° C. for 6 hours
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted with chloroform
  4. dry with materialThe organic layer was dried (MgSO4)
  5. concentrationconcentrated
  6. customThe residue was purified by column chromatography on silica gel (40% ethyl acetate in chloroform)

출처 및 근거

ORD 기록
ord-b9b7c5b046e0459fb54543dbd79ec6ea
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872115

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