Hydrogen Peroxide → 2-Amino-5-(propan-2-yl)benzoic acid

HRID 362916노트

반응식

HRID 362916 반응식
[OH:1]O.[CH:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11]C(=O)[C:9]2=[O:16])([CH3:5])[CH3:4].[OH-].[Na+]>O>[CH:3]([C:6]1[CH:7]=[C:8]([C:9]([OH:16])=[O:1])[C:12]([NH2:11])=[CH:13][CH:14]=1)([CH3:4])[CH3:5]

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 5898025-(propan-2-yl)-1H-indole-2,3-dione

생성물 1

HCID 125621272-Amino-5-(propan-2-yl)benzoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Step 1): 30% H2O2 (6 ml) was added to a solution of 5-isopropyl-1H-indole-2,3-dione [J. Med. Chem., 19, 391(1976)] (4.0 g, 21.1 mmol) in 1N-NaOH (15 ml) at 5° C. The mixture was stirred for 3 hours at room temperature and then poured into H2O and acidified. The precipitates were filtered to give 5-isopropylanthranilic acid, 2.6 g (68.6%): mp 93°-95° C.

후처리

  1. filtrationThe precipitates were filtered

출처 및 근거

ORD 기록
ord-72cdcd4d4e1f40869e1139e550392c5a
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872115

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