Dihydrochalcone → 1,3-Diphenylpropan-1-ol

HRID 363014

반응식

HRID 363014 반응식
[C:1]1([CH2:7][CH2:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+]>C(O)C>[C:11]1([CH:9]([OH:10])[CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 64802DihydrochalconeHCID 4311764Sodium borohydride

생성물 1

HCID 2501291,3-Diphenylpropan-1-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

β-Phenylpropiophenone (6-1) (7.5 g, 36.0 mmol) was suspended in ethanol (100 ml) and sodium borohydride (0.68 g, 18.0 mmol) was added under N2. The resulting solution was stirred at ambient temperature overnight. The ethanol was removed in vacuo and the residual oil-solid was taken up in ethyl acetate (100 ml) and water (30 ml). The ethyl acetate layer was removed, washed with water, dried, filtered and concentrated in vacuo to give 6-2 as a colorless oil.

후처리

  1. customThe ethanol was removed in vacuo
  2. customThe ethyl acetate layer was removed
  3. washwashed with water
  4. customdried
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8f650809c4e84eedb17aac34a747ef24
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872138

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