2-Ethyl-6-methylphenol → 4-Bromo-2-ethyl-6-methylphenol

HRID 363095

반응식

HRID 363095 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:4]=1[OH:10])[CH3:2].[Br-:11].[Br-].[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC>C(Cl)(Cl)Cl>[Br:11][C:7]1[CH:6]=[C:5]([CH3:9])[C:4]([OH:10])=[C:3]([CH2:1][CH3:2])[CH:8]=1

참가 물질

4

반응물 2

HCID 5193332-Ethyl-6-methylphenolHCID 23500184Tetra-n-butylammonium tribromide

생성물 1

HCID 220068384-Bromo-2-ethyl-6-methylphenol수율 182.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Then, 16 g of 2-ethyl-6-methylphenol was dissolved in 200 ml of chloroform, followed by stirring at 0° C., to which 56.6 g of tetrabutylammonium tribromide was added in small portions. After stirring at room temperature for 1 hour, the solvent was removed by distillation under reduced pressure, and the residue was dissolved in 300 ml of diethyl ether. The solution was successively washed with 10% hydrochloric acid and water, dried with anhydrous magnesium sulfate, and concentrated to obtain a crude product. The crude product was subjected to silica gel chromatography, which afforded 23 g of 4-bromo-2-ethyl-6-methylphenol (92% yield).

후처리

  1. additionwas added in small portions
  2. customthe solvent was removed by distillation under reduced pressure
  3. dissolutionthe residue was dissolved in 300 ml of diethyl ether
  4. washThe solution was successively washed with 10% hydrochloric acid and water
  5. dry with materialdried with anhydrous magnesium sulfate
  6. concentrationconcentrated
  7. customto obtain a crude product

출처 및 근거

ORD 기록
ord-12b1d64a1dd3461ba4f2a029abab3055
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872137

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