Anthranilic Acid → N-n-octylanthranilic acid

HRID 36313

반응식

HRID 36313 반응식
[C:1]([OH:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[OH-].[Na+].C1(C)C=CC(S(O[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH2:23]([NH:4][C:3]1[C:2](=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:1]([OH:10])=[O:9])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]

참가 물질

5

반응물 3

HCID 227Anthranilic AcidHCID 14798Sodium HydroxideHCID 599296n-Octyl p-Toluenesulfonate

생성물 1

HCID 15090289N-n-octylanthranilic acid수율 43.1%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
120 °C

실험 절차

To a solution of anthranilic acid in toluene, n-octyl p-toluenesulfonate prepared according to the conventional method was added and the mixture was refluxed at 120° C. After 6 hours, an aqueous solution of sodium hydroxide was added and the toluene layer was concentrated. N-n-octylanthranilic acid was obtained from the remaining reactant after the purification by column chromatography with the yield of 43.1%.

후처리

  1. additionwas added
  2. concentrationthe toluene layer was concentrated

출처 및 근거

ORD 기록
ord-83f0afa4f03c4cc1a583fc651ef4429b
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05413794

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