Water → 6-(2-(Trifluoromethyl)phenyl)nicotinic acid

HRID 363194노트

반응식

HRID 363194 반응식
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]=1.[Mn]([O-])(=O)(=O)=[O:19].[K+].[OH2:24]>>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([OH:19])=[O:24])=[CH:11][N:10]=1

참가 물질

4

반응물 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 53975108HCID 53975108, 화합물

생성물 1

HCID 247299916-(2-(Trifluoromethyl)phenyl)nicotinic acid

실험 절차

A suspension of 2-(2-Trifluoromethylphenyl)-5-methylpyridine (0.40 g, 1.68 mmol) and potassium permanganate (1.60 g, 10.1 mmol), in water (10 mL) was heated at reflux for 16 hours. The reaction was filtered hot through celite to remove the solids. Acetic acid was added to the colourless filtrate to yield a pH of 5 and the resulting suspension was extracted with CH2Cl2, washed with water (10 mL), dried, (MgSO4), and the solvent evaporated in vacuo to afford the title compound.

후처리

  1. temperatureat reflux for 16 hours
  2. filtrationThe reaction was filtered hot through celite
  3. customto remove the solids
  4. additionAcetic acid was added to the colourless filtrate
  5. customto yield a pH of 5
  6. extractionthe resulting suspension was extracted with CH2Cl2
  7. washwashed with water (10 mL)
  8. dry with materialdried, (MgSO4),
  9. customthe solvent evaporated in vacuo

출처 및 근거

ORD 기록
ord-3ec0301730bb4dd5829e024c0c345dbe
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872136

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