Sodium amide → 2-Amino-3-Phenyl-6-methylpyridine

HRID 363199

반응식

HRID 363199 반응식
[C:1]1([C:7]2[CH:8]=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2-:14].[Na+]>CCN(C1C=CC=CC=1)CC>[NH2:14][C:8]1[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:12][CH:11]=[C:10]([CH3:13])[N:9]=1

참가 물질

4

반응물 2

HCID 24533Sodium amideHCID 767442-Methyl-5-phenylpyridine

생성물 1

HCID 463146392-Amino-3-Phenyl-6-methylpyridine

시약·촉매·용매 1

HCID 7061N,N-Diethylaniline용매

실험 절차

A solution of 3-phenyl-6-methyl pyridine (0.815 g, 4.82 mmol), and sodium amide (752 mg, 19.3 mmol) in diethylaniline (10 mL) was heated at 180° C. for 72 hours. The reaction was cooled and quenched with ice (100 g), and the mixture extracted with EtOAc. The organic extract was washed with brine (50 mL), dried (MgSO4), silica gel (100 g) was added and the solvent evaporated in vacuo.

후처리

  1. temperatureThe reaction was cooled
  2. customquenched with ice (100 g)
  3. extractionthe mixture extracted with EtOAc
  4. extractionThe organic extract
  5. washwas washed with brine (50 mL)
  6. dry with materialdried (MgSO4), silica gel (100 g)
  7. additionwas added
  8. customthe solvent evaporated in vacuo

출처 및 근거

ORD 기록
ord-32a3396c1d2b456c8dbc096b5c0cb0df
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05872136

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