Tetrabutylammonium Hydroxide → Tetrabutylammonium

HRID 36325

반응식

HRID 36325 반응식
[I:1][C:2]1[N:10]=[C:9]([NH2:11])[N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.[OH-].[CH2:13]([N+:17]([CH2:26][CH2:27][CH2:28][CH3:29])([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:18][CH2:19][CH2:20][CH3:21])[CH2:14][CH2:15][CH3:16]>C(Cl)Cl>[CH2:26]([N+:17]([CH2:13][CH2:14][CH2:15][CH3:16])([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:22][CH2:23][CH2:24][CH3:25])[CH2:27][CH2:28][CH3:29].[I:1][C:2]1[N:10]=[C:9]([NH2:11])[N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2

참가 물질

5

반응물 2

HCID 2723671Tetrabutylammonium HydroxideHCID 61015752-Amino-6-iodopurine

생성물 2

HCID 16028TetrabutylammoniumHCID 61015752-Amino-6-iodopurine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of 6-iodo-2-aminopurine (1.21 g., 4.637 mmole) in methylene chloride (12 ml.) at room temperature, was added 1.5M tetra(n-butyl)ammonium hydroxide (2.7 ml., 4.05 mmole). The reaction mixture was stirred for 10 minutes, and the volatiles were removed in vacuo. Methylene chloride (12 ml.) was added to the white residue, and the resulting solution was dried (magnesium sulfate), filtered, and the filtrate was concentrated in vacuo to yield the tetra(n-butyl)ammonium salt of 6-iodo-2-aminopurine as a white residue.

후처리

  1. customthe volatiles were removed in vacuo
  2. additionMethylene chloride (12 ml.) was added to the white residue
  3. dry with materialthe resulting solution was dried (magnesium sulfate)
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-b08e4d29c6fd4228ab53668cb15e5f1a
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414000

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