Phosphorus tribromide → 1-(Bromomethyl)-3-chlorobenzene

HRID 36340

반응식

HRID 36340 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]O.P(Br)(Br)[Br:11]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][Br:11]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 701173-Chlorobenzyl alcohol

생성물 1

HCID 698381-(Bromomethyl)-3-chlorobenzene

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

A solution of 260 ul of 3-chlorobenzyl alcohol dissolved in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul of PBr3 added. The reaction is stirred for 3 hours and extracted with ether. The organic layer is washed with saturated sodium bicarbonate and evaporated to give the desired product.

후처리

  1. extractionextracted with ether
  2. washThe organic layer is washed with saturated sodium bicarbonate
  3. customevaporated

출처 및 근거

ORD 기록
ord-2e356bec6541419499a7e4e5503f2522
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414001

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