Phosphorus tribromide → 3-Methoxybenzyl bromide

HRID 36341

반응식

HRID 36341 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]O.P(Br)(Br)[Br:12]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][Br:12]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 814373-Methoxybenzyl alcohol

생성물 1

HCID 40672073-Methoxybenzyl bromide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 270 ul of 3-methoxybenzyl alcohol in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul PBr3 added, followed by stirring for three hours. The reaction mixture is extracted with ether and the organic layer washed with saturated sodium bicarbonate and evaporated to give the desired product.

후처리

  1. extractionThe reaction mixture is extracted with ether
  2. washthe organic layer washed with saturated sodium bicarbonate
  3. customevaporated

출처 및 근거

ORD 기록
ord-d0021b55fed847d8be332381521d5721
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414001

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