Phosphorus tribromide → 3-Methoxybenzyl bromide
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]O.P(Br)(Br)[Br:12]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][Br:12]참가 물질
4
실험 절차
A solution of 270 ul of 3-methoxybenzyl alcohol in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul PBr3 added, followed by stirring for three hours. The reaction mixture is extracted with ether and the organic layer washed with saturated sodium bicarbonate and evaporated to give the desired product.
후처리
- extractionThe reaction mixture is extracted with ether
- washthe organic layer washed with saturated sodium bicarbonate
- customevaporated
출처 및 근거
- ORD 기록
- ord-d0021b55fed847d8be332381521d5721
- 출처 데이터셋
- uspto-grants-1995_05
- 특허 번호
- US05414001
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