3-Bromobenzoic acid → 1-Bromo-3-tert-butylbenzene

HRID 36344

반응식

HRID 36344 반응식
[C:1]([C:5]1[CH:6]=[C:7](C#C)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[Br:13]C1C=C(C=CC=1)C(O)=O.C[Al](C)C>CCCCCC>[C:1]([C:5]1[CH:6]=[C:7]([Br:13])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 114563-Bromobenzoic acid2회HCID 149896671-(tert-Butyl)-3-ethynylbenzene2회HCID 16682925Trimethylaluminum

생성물 1

HCID 3437981-Bromo-3-tert-butylbenzene

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Reaction Scheme 4 discloses a specific synthetic route to 3-tert-butylphenyl ethyne (Compound 22) starting with meta bromobenzoic acid (Compound 23), which is treated with trimethylaluminum in hexane to yield 3-tert-butyl bromobenzene (Compound 24). 3-Tert-butyl bromobenzene 24 is thereafter converted into the ethyne derivative 22 through the trimethylsilyl ethyne intermediate 25 in steps similar to the steps described in connection with Reaction Scheme 3.

후처리

  1. customReaction Scheme 4

출처 및 근거

ORD 기록
ord-1545945aa4924efca8fa5810dddf53f3
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414007

연결된 노트

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