Toluene → 4-Amino-3-chloro-5-methoxyiminomethylbenzoyl chloride

HRID 363493

반응식

HRID 363493 반응식
[NH2:1][C:2]1[C:10]([CH:11]=[N:12][O:13][CH3:14])=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[Cl:15].C1(C)C=CC=CC=1.S(Cl)([Cl:25])=O>CN(C)C=O>[NH2:1][C:2]1[C:10]([CH:11]=[N:12][O:13][CH3:14])=[CH:9][C:5]([C:6]([Cl:25])=[O:7])=[CH:4][C:3]=1[Cl:15]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 540991344-Amino-3-chloro-5-methoxyiminomethylbenzoic acid

생성물 1

HCID 544540514-Amino-3-chloro-5-methoxyiminomethylbenzoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

In a 5-liter three-necked round-bottomed flask was placed 180 g of the previously prepared 4-amino-3-chloro-5-methoxyiminomethylbenzoic acid, 2 l of toluene, 3 mL of dimethylformamide and 104 g (64 mL) of thionyl chloride. The resulting mixture was heated at 70° C. for 2 hours, filtered while hot and the solvent removed using a rotary evaporator yielding 178.1 g of the expected 4-amino-3-chloro-5-methoxyiminomethylbenzoyl chloride.

후처리

  1. customIn a 5-liter three-necked round-bottomed flask was placed
  2. filtrationfiltered while hot and the solvent
  3. customremoved
  4. customa rotary evaporator

출처 및 근거

ORD 기록
ord-093d5ecf5a8647b684fe6f3e10bff9f9
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05874466

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