2-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanol → 2-[(3-Pyrrolidinylmethyl)amino]ethanol

HRID 364048

반응식

HRID 364048 반응식
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[NH:8]1[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]1

참가 물질

5

반응물 2

HCID 142808882-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 134918032-[(3-Pyrrolidinylmethyl)amino]ethanol수율 57.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 32.32 g of 2-[[[1-(phenylmethyl)3-pyrrolidinyl]methyl]amino]ethanol, 330 ml of methanol and 3 g of 20% palladium on charcoal was shaken in an atmosphere of hydrogen at about 50 psi and at room temperature for 18 hours. The solvents were then removed at reduced pressure. The residue was distilled under vacuum (bp 129°-131° C. 1.5 mm Hg) to give 11.43 g of 2-[(3-pyrrolidinyl methyl)amino] ethanol.

후처리

  1. customThe solvents were then removed at reduced pressure
  2. distillationThe residue was distilled under vacuum (bp 129°-131° C. 1.5 mm Hg)

출처 및 근거

ORD 기록
ord-999c7c4945a147c4b5b1ed4dd7eaeba5
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604401

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