(3,4-Dimethoxyphenyl)acetic acid → (3,4-Dimethoxyphenyl)acetyl chloride

HRID 364067

반응식

HRID 364067 반응식
S(Cl)([Cl:3])=O.[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH2:15][C:16]([OH:18])=O)[CH:10]=[CH:11][C:12]=1[O:13][CH3:14]>C(Cl)Cl>[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH2:15][C:16]([Cl:3])=[O:18])[CH:10]=[CH:11][C:12]=1[O:13][CH3:14]

참가 물질

4

반응물 2

HCID 7139(3,4-Dimethoxyphenyl)acetic acidHCID 24386Thionyl Chloride

생성물 1

HCID 3604458(3,4-Dimethoxyphenyl)acetyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thionyl chloride (600 ml) is added dropwise, with stirring, over a period of 2 hours, to a suspension of 3,4-dimethoxy-phenylacetic acid (549.4 g) in methylene chloride (600 ml). After the development of gas has ended (16 hours) the mixture is refluxed for a further hour. After the highly volatile components have been removed the residue is distilled in vacuo.

후처리

  1. custom(16 hours)
  2. temperatureis refluxed for a further hour
  3. customAfter the highly volatile components have been removed the residue
  4. distillationis distilled in vacuo

출처 및 근거

ORD 기록
ord-84c79170daf541418aa1ecc3cbc7f128
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604389

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