Hydrochloric Acid → 2-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid

HRID 364175노트

반응식

HRID 364175 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:21]([O-:23])=[O:22])=[C:6]([CH:20]=1)[O:7][C:8]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:9]=1[C:10]([O:12]C)=[O:11].[OH-].[K+].Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:21]([O-:23])=[O:22])=[C:6]([CH:20]=1)[O:7][C:8]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:9]=1[C:10]([OH:12])=[O:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 136890962-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid, methyl ester

생성물 1

HCID 136890952-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred suspension of 65 g of 2-(5-chloro-2-nitrophenoxy)-5-methoxybenzoic acid, methyl ester, in 600 ml of methanol, was added 97.5 ml of 6M KOH solution. This suspension was stirred for 18 hours and the solution which resulted was neutralized with 200 ml of 10% HCl solution. The precipitated crude acid product was collected by filtration and, after recrystallization from acetonitrile, yielded the title compound, mp 232°-234° C.

후처리

  1. customthe solution which resulted
  2. customThe precipitated crude acid product
  3. filtrationwas collected by filtration
  4. customafter recrystallization from acetonitrile

출처 및 근거

ORD 기록
ord-274139536c184ed5bdb934812ae3ee22
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604390

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