Formic Acid → 3-(4-Nitrophenyl)propanoic acid

HRID 36420

반응식

HRID 36420 반응식
CC1(C)[O:9][C:7](=[O:8])[CH2:6][C:4](=O)O1.[N+:11]([C:14]1[CH:21]=[CH:20][C:17](C=O)=[CH:16][CH:15]=1)([O-:13])=[O:12].C(O)=O>C(N(CC)CC)C>[N+:11]([C:14]1[CH:21]=[CH:20][C:17]([CH2:4][CH2:6][C:7]([OH:9])=[O:8])=[CH:16][CH:15]=1)([O-:13])=[O:12]

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 5414-NitrobenzaldehydeHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

생성물 1

HCID 855263-(4-Nitrophenyl)propanoic acid

시약·촉매·용매 1

HCID 8471Triethylamine용매

반응 조건

온도
105 °C

실험 절차

3.60 g (0.025 mol) of Meldrum's acid and 3.8 g (0.025 mol) of p-nitrobenzaldehyde were weighed in to 25 ml of the mixture of formic acid and triethylamine prepared as described in Example l. The reaction mixture was heated to 105° C. during 1 hour and reacted at the same temperature for 1 hour. The product was isolated according to Example 1.

후처리

  1. customprepared
  2. customreacted at the same temperature for 1 hour
  3. customThe product was isolated

출처 및 근거

ORD 기록
ord-34d196c1fab248819f8d6892c2587e9f
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414108

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