Sodium → HCID 20240529, 화합물

HRID 364230노트

반응식

HRID 364230 반응식
[Na].[CH3:2][O-:3].[Na+].Cl[C:6]1[CH:11]=[C:10]([CH2:12][N:13]2[C:17](=[O:18])[C:16]3=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]3[C:14]2=[O:23])[N:9]=[C:8]([S:24][CH3:25])[N:7]=1>CO>[CH3:2][O:3][C:6]1[CH:11]=[C:10]([CH2:12][N:13]2[C:17](=[O:18])[C:16]3=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]3[C:14]2=[O:23])[N:9]=[C:8]([S:24][CH3:25])[N:7]=1

참가 물질

5

반응물 3

HCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 13377335HCID 13377335, 화합물

생성물 1

HCID 20240529HCID 20240529, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 100 ml of methanol was added 1.55 g (67.4 mmole) of sodium metal to prepare 67.4 mmole of sodium methoxide. To this solution was added 20.0 g (62.6 mmole) of 4-chloro-2-methylthio-6-phthalimidomethylpyrimidine (from Example 2) and the mixture was heated at reflux for 16 hours. The mixture was cooled, and the solid was then separated by filtration. This solid was washed sequentially with methanol and water to provide 4-methoxy-2-methylthio-6-phthalimidomethylpyrimidine as a white solid. The structural assignment was confirmed by infrared and nuclear magnetic resonance spectral analyses.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 16 hours
  3. temperatureThe mixture was cooled
  4. customthe solid was then separated by filtration
  5. washThis solid was washed sequentially with methanol and water

출처 및 근거

ORD 기록
ord-08c5264727eb4a5fa1be2c76da6a44ab
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604466

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