4-Pyridinepropaneamide → 4-Pyridinepropanenitrile

HRID 364717

반응식

HRID 364717 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][C:9]([NH2:11])=O)=[CH:3][CH:2]=1>O=P(Cl)(Cl)Cl>[C:9]([CH2:8][CH2:7][C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1)#[N:11]

참가 물질

3

반응물 1

HCID 37782334-Pyridinepropaneamide

생성물 1

HCID 73304614-Pyridinepropanenitrile수율 77%

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

A mixture of 3-(4-pyridyl)-propionamide (7.1 g, 0.47M) in POCl3 (25 ml) was heated at about 100° to about 110° C. for 2 hrs. The excess of POCl3 was removed in vacuo from the reaction. Thereafter water was added and the resulting solution was basified with aqueous Na2CO3 sol. and extracted with CHCl3. The combined extracts were dried over Na2SO4 and concentrated and distilled at 1 mmHg/118°-120° C. to give 4(2-cyanoethyl)pyridine as an oil (4.8 g, 77% yield).

후처리

  1. temperaturewas heated at about 100° to about 110° C. for 2 hrs
  2. customThe excess of POCl3 was removed in vacuo from the reaction
  3. additionThereafter water was added
  4. extractionextracted with CHCl3
  5. dry with materialThe combined extracts were dried over Na2SO4
  6. concentrationconcentrated
  7. distillationdistilled at 1 mmHg/118°-120° C.

출처 및 근거

ORD 기록
ord-f4fbddcfe74a42fbb1968b95d9344d80
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04605744

연결된 노트

불러오는 중…