Hydrochloric Acid → 4-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine

HRID 364735노트

반응식

HRID 364735 반응식
[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1)[CH3:2].Cl>C(O)C.O.[Pt]=O>[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][CH:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1)[CH3:2]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 137267364-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine

생성물 1

HCID 134731494-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine수율 70.6%

시약·촉매·용매 3

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

The solution of 4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine (1.1 g, 0.0054M) in ethanol (15 ml) and water (15 ml) was added con.HCl (3 ml) and platinum oxide (0.2 g). The mixture was hydrogenated at 45 psig for 4 hrs. The catalyst was removed by filtration and the filtrate was stripped to dryness in vacuo. The residue was dissolved in methanol (25 ml) and sodium methoxide (0.011M) was added and filtered. The filtrate was stripped to dryness and distilled at about 150° to about 175° C./0.2 mm Hg to yield 4-[2-(1-ethyl-4,5-dihydro-imdazol-2-yl)ethyl]piperidine as an oil (0.8 g, 70% yield).

후처리

  1. customThe catalyst was removed by filtration
  2. dissolutionThe residue was dissolved in methanol (25 ml)
  3. additionsodium methoxide (0.011M) was added
  4. filtrationfiltered
  5. distillationdistilled at about 150° to about 175° C./0.2 mm Hg

출처 및 근거

ORD 기록
ord-0d3666a787654767a2885baddfed68b6
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04605744

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