Phenyl Isothiocyanate → 1-Piperazinecarbothioamide, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-phenyl-

HRID 364888노트

반응식

HRID 364888 반응식
[N:1]1([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=3)[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:22]1([N:28]=[C:29]=[S:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O1CCOCC1>[C:22]1([NH:28][C:29]([N:4]2[CH2:5][CH2:6][N:1]([C:7]3[N:16]=[C:15]([NH2:17])[C:14]4[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=4)[N:8]=3)[CH2:2][CH2:3]2)=[S:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 2

HCID 7673Phenyl IsothiocyanateHCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline

생성물 1

HCID 30614491-Piperazinecarbothioamide, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-phenyl-수율 69.9%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

In 20 ml of dioxane, there was dissolved 0.87 g. (3 mmole) of 2-piperazino-4-amino-6,7-dimethoxyquinazoline. To the resultant solution was added dropwise a solution of 0.41 g. (3 mmole) of phenylisothiocyanate dissolved in 10 ml of dioxane at room temperature. The mixture was further stirred overnight. After evaporation of the solvent, the residue was chromatographed on silica gel and eluted with 20% dioxane-chloroform to obtain 0.89 g. of the desired product.

후처리

  1. customAfter evaporation of the solvent
  2. customthe residue was chromatographed on silica gel
  3. washeluted with 20% dioxane-chloroform
  4. customto obtain 0.89 g

출처 및 근거

ORD 기록
ord-04adfef2fbde4940b6b617c27477a4cd
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04607034

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