Hydrochloric Acid → 2-Aminomethyl-4-(1,1-dimethylethyl)-6-methylsulfamoylphenol hydrochloride

HRID 364899노트

반응식

HRID 364899 반응식
C([NH:4][CH2:5][C:6]1[C:11]([OH:12])=[C:10]([S:13](=[O:17])(=[O:16])[NH:14][CH3:15])[CH:9]=[C:8]([C:18]([CH3:21])([CH3:20])[CH3:19])[CH:7]=1)(=O)C.[ClH:22]>C(O)C>[ClH:22].[NH2:4][CH2:5][C:6]1[CH:7]=[C:8]([C:18]([CH3:20])([CH3:21])[CH3:19])[CH:9]=[C:10]([S:13](=[O:17])(=[O:16])[NH:14][CH3:15])[C:11]=1[OH:12]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 132103502-Acetamidomethyl-4-(1,1-dimethylethyl)-6-methylsulfamoylphenol

생성물 1

HCID 212969082-Aminomethyl-4-(1,1-dimethylethyl)-6-methylsulfamoylphenol hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4.9 g (0.016 mole) of 6-acetamidomethyl-4-(1,1-dimethylethyl)-2-methylsulfamoylphenol in a mixture of 30 ml of ethanol and 10 ml of concentrated hydrochloric acid are heated under reflux for 8 hours. Evaporation and recrystallization from methanol/ether gives white crystals of melting point 238°-240° C.

후처리

  1. temperatureare heated
  2. temperatureunder reflux for 8 hours
  3. customEvaporation and recrystallization from methanol/ether
  4. customgives white crystals of melting point 238°-240° C.

출처 및 근거

ORD 기록
ord-b0e8f4ca4888446db51d560e8ac29e56
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04607030

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