Ethylparaben → Ethyl 4-[2-Oxo-2-(phenylmethoxy)ethoxy]benzoate

HRID 36491

반응식

HRID 36491 반응식
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.Br[CH2:14][C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[O:16]=[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:14][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:11][CH:12]=1

참가 물질

6

반응물 3

HCID 8434EthylparabenHCID 11430Potassium CarbonateHCID 62576Benzyl bromoacetate

생성물 1

HCID 53990693Ethyl 4-[2-Oxo-2-(phenylmethoxy)ethoxy]benzoate수율 99%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of ethyl p-hydroxybenzoate (4.98 g), benzyl bromoacetate (4.75 ml) and K2CO3 (4.14 g) was stirred for 15 hr in 30 ml of DMF. The reaction mixture was diluted with water (200 ml) and extracted with a 1:1 ether:hexane mixture. The combined organic extracts were washed (water, brine), dried (Na2SO4), filtered, and evaporated leaving 9.3 g, (99%) of the title compound as a heavy oil; TLC, Rf =0.71, Et2O: hexane (1:1).

후처리

  1. extractionextracted with a 1:1 ether
  2. washThe combined organic extracts were washed (water, brine)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-76c44d27eb4b427882d1bb80398ab9ef
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414132

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