Ammonia → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

HRID 364910

반응식

HRID 364910 반응식
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](Cl)(=[O:18])=[O:17])[C:8]=1[OH:20])=[O:4].[NH3:21]>CC(C)=O.O>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](=[O:18])(=[O:17])[NH2:21])[C:8]=1[OH:20])=[O:4]

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

생성물 1

HCID 132103556-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

33.8 g (0.1 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane are dissolved in a little acetone, and the solution is added dropwise to 50 ml of concentrated ammonia solution. The mixture is stirred for 30 minutes at room temperature and is diluted with water. The precipitate which is deposited is filtered off with suction and dissolved in acetone, and the solution is filtered and stirred into water again.

후처리

  1. filtrationThe precipitate which is deposited is filtered off with suction
  2. dissolutiondissolved in acetone
  3. filtrationthe solution is filtered
  4. stirringstirred into water again

출처 및 근거

ORD 기록
ord-014011e3e98841fd98e40d5753661173
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04607030

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