p-Bromobenzenesulfonyl chloride → N-Benzyl-4-bromobenzenesulfonamide
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH2:12]([NH2:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:19][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1참가 물질
4
실험 절차
4-Bromobenzenesulfonyl chloride (14.05 g, 55 mmol) was added to a stirred solution of benzylamine (5.36 g, 50 mmol) and pyridine (400 ml) under nitrogen at room temperature. The resulting reaction mixture was stirred for 1 hr; then it was poured onto ice/water (800 ml) to form a yellow precipitate which was filtered and recrystallized from EtOH/water to give 9.44 g (53%) of the title compound as off-white needles, mp 116°-117° C.
후처리
- customThe resulting reaction mixture
- additionthen it was poured onto ice/water (800 ml)
- customto form a yellow precipitate which
- filtrationwas filtered
- customrecrystallized from EtOH/water
출처 및 근거
- ORD 기록
- ord-3b203ffad0524e8a81568be747831d0e
- 출처 데이터셋
- uspto-grants-1995_05
- 특허 번호
- US05414132
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