Water → HCID 13292600, 화합물

HRID 364997노트

반응식

HRID 364997 반응식
[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][OH:10])[CH:4]=1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+].O>O1CCCC1>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][OH:10])[CH:4]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 132925992-(Hydroxymethyl)pyridine-4-carbonitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 13292600HCID 13292600, 화합물수율 54.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

실험 절차

A solution of 4-cyano-2-hydroxymethylpyridine (0.5 g) in tetrahydrofuran (25 ml) was added dropwise over 20 minutes to a stirred mixture of lithium aluminium hydride (0.25 g) in tetrahydrofuran (30 ml) and the mixture was stirred at room temperature for 2 hours. Wet tetrahydrofuran followed by 0.35 ml of 16% w/w aqueous sodium hydroxide and water were added and the mixture was filtered. The filtrate was evaporated to give crude 4-aminomethyl-2-hydroxymethylpyridine (0.28 g).

후처리

  1. additionwere added
  2. filtrationthe mixture was filtered
  3. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-e89e369c398640a0beddf2a8300ce4a8
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04607107

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