Methyl iodide → methyl 3-fluoro-2-formylbenzoate
반응식
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]([OH:12])[O:5][C:6]2=[O:7].[C:13](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[F:1][C:2]1[C:3]([CH:4]=[O:12])=[C:8]([CH:9]=[CH:10][CH:11]=1)[C:6]([O:5][CH3:13])=[O:7]참가 물질
5
실험 절차
A stirred mixture containing 7.36 g 4-fluoro-3-hydroxyphthalide, 18.15 g potassium carbonate and 11 mL methyl iodide in 125 mL acetone is heated at reflux for two hours. After stirring overnight at room temperature, the mixture is filtered and concentrated. The residue is dispersed in 200 mL ether, filtered and the filtrate concentrated to give 7.6 g residue which is used directly without further purification. The nmr spectrum of this material is consistent with that expected for the desired product.
후처리
- temperatureis heated
- temperatureat reflux for two hours
- filtrationthe mixture is filtered
- concentrationconcentrated
- additionThe residue is dispersed in 200 mL ether
- filtrationfiltered
- concentrationthe filtrate concentrated
출처 및 근거
- ORD 기록
- ord-39d89443bea04959ac5d2f4d9021f4e1
- 출처 데이터셋
- uspto-grants-1986_08
- 특허 번호
- US04608079
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