1,2-Dimethylhydrazine → 3-Hydroxy-1,2,4-trimethyl-5-pyrazolone

HRID 365173

반응식

HRID 365173 반응식
[CH3:1][CH:2]([C:8]([O:10]CC)=O)[C:3](OCC)=[O:4].[CH3:13][NH:14][NH:15][CH3:16].C[O-].[Na+]>CO>[OH:10][C:8]1[N:14]([CH3:13])[N:15]([CH3:16])[C:3](=[O:4])[C:2]=1[CH3:1]

참가 물질

5

반응물 3

HCID 13221,2-DimethylhydrazineHCID 11857Diethyl methylmalonateHCID 10942334Sodium Methoxide

생성물 1

HCID 128188533-Hydroxy-1,2,4-trimethyl-5-pyrazolone

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Diethyl methylmalonate and N,N'-dimethylhydrazine are heated under reflux for 170 hours in methanol in the presence of sodium methylate under an atmosphere of nitrogen. 3-Hydroxy-1,2,4-trimethyl-5-pyrazolone is obtained in the form of colorless crystals which, after recrystallization from ethyl acetate, melt at 87°-89° C.

출처 및 근거

ORD 기록
ord-da58efdd8cfd44639ad1ce4e0173a134
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04608383

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