3,6-Dichloropyridazine → HCID 20237843, 화합물

HRID 365199노트

반응식

HRID 365199 반응식
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[O:9]([CH2:16][CH:17]([OH:23])[CH2:18][NH:19][CH2:20][CH2:21][NH2:22])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(C(C)C)C(C)C)C>C1(C)C=CC=CC=1>[O:9]([CH2:16][CH:17]([OH:23])[CH2:18][NH:19][CH2:20][CH2:21][NH:22][C:5]1[N:4]=[N:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 673313,6-DichloropyridazineHCID 81531DiisopropylethylamineHCID 145507661-[(2-Aminoethyl)amino]-3-phenoxypropan-2-ol

생성물 1

HCID 20237843HCID 20237843, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 3.0 g. 3,6-dichloropyridazine, 4.2 g. 1-phenoxy-3-(2-aminoethylamino)-propan-2-ol, 3.5 ml. N-ethyldiisopropylamine and 30 ml. toluene is stirred for 24 hours at 100° C. The reaction mixture is then evaporated and the residue is digested simultaneously with 100 ml. water and 100 ml. methylene chloride, followed by suction filtration and recrystallization from isopropyl alcohol, with treatment with fullers' earth. There are obtained 1.4 g. (21% of theory) of the desired product in the form of colorless crystals; m.p. 147°-149° C.

후처리

  1. additionA mixture of 3.0 g
  2. customThe reaction mixture is then evaporated
  3. filtrationmethylene chloride, followed by suction filtration and recrystallization from isopropyl alcohol, with treatment with fullers' earth
  4. customThere are obtained 1.4 g

출처 및 근거

ORD 기록
ord-e1b8b2da957a46dc8f9bbb3b24e0fce7
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04608383

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